*Deep movie announcer voice* In a world where Email must go through arises a new hero! Only he could fully apply the changes made to receive connectors without destroying the WORLD!
Okay, not really. But I wrote a script that will run through all of the Exchange servers in an environment and restart the transport servers on each. This is a rolling restart process, which keeps the impact to mail-flow as limited as possible. I would estimate no more than 20 seconds of delay from running this script at any time. No lost email, as the mail queues are not modified in any way.
At any rate, go check it out on my Technet Gallery.